Mirati, Aadi To Evaluate Adagrasib, Nab-sirolimus Combination To Treat NSCLC, Other Solid Tumors

RTTNews | il y a 842
Mirati, Aadi To Evaluate Adagrasib, Nab-sirolimus Combination To Treat NSCLC, Other Solid Tumors

(RTTNews) - Oncology company Mirati Therapeutics, Inc. (MRTX) and biopharmaceutical company Aadi Bioscience, Inc. (AADI) announced Wednesday a clinical collaboration to evaluate the combination of adagrasib, a KRASG12C selective inhibitor, and nab-sirolimus, a small molecule mTOR inhibitor complexed with human albumin in KRAS G12C mutant non-small cell lung cancer (NSCLC) and other solid tumors.

The primary objective of this multi-center, single-arm, open-label Phase 1/2 trial is to determine the optimal dose and recommended Phase 2 dose for the combination of adagrasib and nab-sirolimus in patients with KRASG12C - mutant solid tumors.

In addition, the study will investigate the safety, tolerability and efficacy of adagrasib and nab-sirolimus in combination in patients both with and without prior exposure to a KRASG12C inhibitor.

The trial will build on preclinical data showing enhanced anti-tumor efficacy with the combination of adagrasib and nab-sirolimus relative to either agent alone.

Under the terms of the collaboration agreement, Mirati will be responsible for sponsoring and operating the Phase 1/2 study, and jointly with Aadi, will oversee and share the cost of the study.

For More Such Health News, visit rttnews.com

read more
France Inflation Rises To 5-Month High

France Inflation Rises To 5-Month High

French inflation accelerated to a five-month high in January largely on energy and manufactured product prices, provisional data from the statistical office INSEE showed Friday. Consumer prices registered an annual increase of 1.4 percent in January, following December's 1.3 percent rise.
RTTNews | il y a 5h 21min
FTSE 100 Hits Fresh Record High

FTSE 100 Hits Fresh Record High

U.K. stocks are up in positive territory Friday morning, and the benchmark FTSE 100 looks set to end the month with a strong gain, as the mood remains a bit bullish amid optimism about more monetary easing by central banks in the coming months.
RTTNews | il y a 6h 29min
German Unemployment Rises Marginally

German Unemployment Rises Marginally

Germany's unemployment rose slightly and job vacancies decreased in January as the manufacturing sector faces severe downturn, official data revealed on Friday. The number of people out of work increased by 11,000 in January after rising 10,000 in December, the Federal Employment Agency said. Unemployment was expected to increase more sharply by 14,000.
RTTNews | il y a 6h 55min
CAC 40 Modestly Higher After Inflation Data

CAC 40 Modestly Higher After Inflation Data

French stocks are up in positive territory Friday morning, as investors continue to cheer the European Central Bank's rate cut decision and the dovish remarks suggesting the possibility of more monetary easing in the coming months.
RTTNews | il y a 7h 13min
UK House Price Growth Slows More Than Forecast

UK House Price Growth Slows More Than Forecast

UK house prices growth slowed more than expected in January largely reflecting high mortgage rates, data published by the Nationwide Building Society showed on Friday. House prices gained only 0.1 percent in January. This follows a 0.7 percent increase in December and also came in weaker than economists' forecast of 0.3 percent.
RTTNews | il y a 8h 9min
DAX Advances, Hovers Around Record High

DAX Advances, Hovers Around Record High

German stocks are edging higher in cautious trade Friday morning with investors digesting the nation's retail sales and unemployment data, and looking ahead to the consumer price inflation report due later in the day.
RTTNews | il y a 8h 11min