Foghorn Therapeutics Says FDA Places Clinical Hold On Phase 1 Dose Escalation Study Of FHD-286

RTTNews | vor 870 Tagen
Foghorn Therapeutics Says FDA Places Clinical Hold On Phase 1 Dose Escalation Study Of FHD-286

(RTTNews) - Biotechnology company Foghorn Therapeutics Inc. (FHTX) announced Tuesday that the U.S. Food and Drug Administration (FDA) has placed a full clinical hold on the Phase 1 dose escalation study of FHD-286, an inhibitor of BRG1/BRM, in relapsed and/or refractory acute myelogenous leukemia (AML) and myelodysplastic syndrome (MDS).

The dose escalation Phase 1 study of FHD-286 in metastatic uveal melanoma (mUM) continues per protocol. The company plans to report data from the mUM study in the first half of 2023.

The full clinical hold in the AML/MDS study is due to the observation, in the data submitted in response to the partial hold, of additional suspected cases of fatal differentiation syndrome believed to be associated with FHD-286.

The FDA has additional questions and requires further analyses before the clinical hold may be lifted.

read more
Japanese Market Notably Lower

Japanese Market Notably Lower

Extending the losses in the previous two sessions, the Japanese market is notably lower on Friday, following the mixed cues from European markets and lack of cues from Wall Street overnight as they were closed. The Nikkei 225 is falling well below the 39,300 level, with weakness across most sectors led by index heavyweights and financial stocks. Technology stocks are the only bright spot.
RTTNews | vor 5Std 14 Minuten
Australian Market Notably Lower

Australian Market Notably Lower

The Australian stock market is notably lower on Friday, extending the losses in the previous session, following the mixed cues from European markets and lack of cues from Wall Street overnight as they were closed. The benchmark S&P/ASX 200 is falling below the 8,300 level, with weakness in financial and technology stocks partially offset by gains in mining and energy stocks.
RTTNews | vor 5Std 38 Minuten
Higher Open Called For Thai Stock Market

Higher Open Called For Thai Stock Market

The Thai stock market has moved lower in consecutive trading days, surrendering almost 30 points or 2.2 percent along the way. The Stock Exchange of Thailand now sits just above the 1,360-point plateau although it nay see bargain hunting on Friday.
RTTNews | vor 5Std 41 Minuten
Mild Upside Seen For Indonesia Stock Market

Mild Upside Seen For Indonesia Stock Market

The Indonesia stock market has moved lower in two straight sessions, slipping almost 20 points or 0.3 percent along the way. The Jakarta Composite Index now sits just above the 7,060-point plateau although it's expected to open in the green on Friday.
RTTNews | vor 6Std 11 Minuten
Hong Kong Stock Market May Stop The Bleeding On Friday

Hong Kong Stock Market May Stop The Bleeding On Friday

The Hong Kong stock market has finished lower in four straight sessions, retreating more than 520 points or 2.8 percent along the way. The Hang Seng Index now sits just above the 19,240-point plateau although it's due for support on Friday.
RTTNews | vor 6Std 26 Minuten
China Stock Market May Reverse Thursday's Losses

China Stock Market May Reverse Thursday's Losses

The China stock market on Thursday wrote a finish to the two-day winning streak in which it had improved almost 25 points or 0.8 percent. The Shanghai Composite Index now sits just above the 3,210-point plateau although it may tock back to the upside on Friday.
RTTNews | vor 6Std 41 Minuten