Carisma Says FDA Grants Fast Track Designation For CT-0525 In HER2-Overexpressing Solid Tumors

RTTNews | vor 130 Tagen
Carisma Says FDA Grants Fast Track Designation For CT-0525 In HER2-Overexpressing Solid Tumors

(RTTNews) - Biopharmaceutical company Carisma Therapeutics, Inc. (CARM) announced Tuesday that the U.S. Food and Drug Administration (FDA) has granted Fast Track designation for CT-0525, an ex vivo gene-modified autologous chimeric antigen receptor-monocyte (CAR-Monocyte) cellular therapy intended to treat solid tumors that overexpress human epidermal growth factor receptor 2 (HER2).

The Phase 1 clinical trial for CT-0525 is an open-label study designed to assess the safety, tolerability, and manufacturing feasibility of CT-0525.

This trial will enroll participants with locally advanced (unresectable) or metastatic solid tumors overexpressing HER2 whose disease has progressed on standard approved therapies. The initial study design will consist of two dose escalation cohorts.

Carisma said it is looking to work closely with the FDA to accelerate the development of CT-0525. It is currently enrolling patients in the Phase 1 clinical trial and remains on track to report initial clinical data by the end of 2024.

read more
TSX Ends On Firm Note As Technology, Consumer Discretionary Stocks Rally

TSX Ends On Firm Note As Technology, Consumer Discretionary Stocks Rally

Canadian benchmark stock index ended with a modest gain on Friday, lifted by strong gains in technology and consumer discretionary sectors. Upbeat earnings updates from big name U.S. companies Intel and Amazon contributed significantly to the firm undertone on Bay Street.
RTTNews | vor 22Std 53 Minuten
Dollar Rises Against Major Counterparts Ahead Of Eventful Week

Dollar Rises Against Major Counterparts Ahead Of Eventful Week

The U.S. dollar suffered a mild setback in early New York session on Friday after data showing a much smaller than expected increase in non-farm payroll employment growth and an unexpected contraction in the nation's manufacturing activity last month.
RTTNews | vor 23Std 24 Minuten
Swiss Market Ends On Firm Note On Strong Economic Data

Swiss Market Ends On Firm Note On Strong Economic Data

The Switzerland market closed on a strong note on Friday, in line with markets across Europe, as upbeat results from top U.S. firms Intel and Amazon, and data showing an unexpected drop in Swiss consumer price inflation helped underpin sentiment.
RTTNews | vor 1 Tagen
Pound Firms Against Majors

Pound Firms Against Majors

The pound moved up against its major counterparts in the New York session on Friday.
RTTNews | vor 1 Tagen
U.S. Construction Spending Inches Slightly Higher In September

U.S. Construction Spending Inches Slightly Higher In September

Reflecting an increase in spending on public construction, the Commerce Department released a report on Friday showed an uptick by U.S. construction spending in the month of September. The report said construction spending crept up by 0.1 percent to an annual rate of $2.149 trillion in September after inching up by 0.1 percent to a revised rate of $2.146 trillion in August.
RTTNews | vor 1 Tagen
U.S. Manufacturing Index Unexpectedly Dips To Lowest Level In Over A Year

U.S. Manufacturing Index Unexpectedly Dips To Lowest Level In Over A Year

A report released by the Institute for Supply Management on Friday showed U.S. manufacturing activity unexpectedly contracted at a modestly faster rate in the month of October. The ISM said its manufacturing PMI fell to 46.5 in October from 47.2 in September, with a reading below 50 indicating contraction. Economists had expected the index to inch up to 47.6.
RTTNews | vor 1 Tagen