Vertex Receives CHMP Positive Opinion For The First CRISPR/Cas9 Gene-Edited Therapy CASGEVY

RTTNews | 441 days ago
Vertex Receives CHMP Positive Opinion For The First CRISPR/Cas9 Gene-Edited Therapy CASGEVY

(RTTNews) - Vertex Pharmaceuticals Inc. (VRTX) announced Friday that the European Medicines Agency's (EMA's) Committee for Medicinal Products for Human Use (CHMP) has adopted a positive opinion for the conditional approval of CASGEVY (exagamglogene autotemcel [exa-cel]), a CRISPR/Cas9 gene-edited therapy, for the treatment of severe sickle cell disease (SCD) and transfusion-dependent beta thalassemia (TDT).

If approved, exa-cel would be the only genetic therapy for patients in the European Union who are 12 years of age and older with either severe SCD with recurrent vaso-occlusive crises (VOCs) or TDT, for whom hematopoietic stem cell (HSC) transplantation is appropriate and a human leukocyte antigen matched related HSC donor is not available.

An approval decision by the European Commission is expected in February 2024.

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Vertex Pharma Inks Licensing Agreement To Use CRISPR Therapeutics' Gene Editing Technology

Vertex Pharma Inks Licensing Agreement To Use CRISPR Therapeutics' Gene Editing Technology

Biotechnology company Vertex Pharmaceuticals, Inc. (VRTX) and gene editing company CRISPR Therapeutics, Inc. (CRSP) announced Monday that they have entered into a new non-exclusive licensing agreement for the use of CRISPR Therapeutics' gene editing technology, known as CRISPR/Cas9, to accelerate the development of Vertex's hypoimmune cell therapies for type 1 diabetes (T1D).
RTTNews | 704 days ago
Vertex Pharma To Acquire ViaCyte For $320 Mln In Cash

Vertex Pharma To Acquire ViaCyte For $320 Mln In Cash

Vertex Pharmaceuticals Inc. (VRTX) announced Monday that the company has entered into a definitive agreement under which Vertex will acquire privately-held biotechnology company ViaCyte for $320 million in cash.
RTTNews | 963 days ago
Vertex Pharma Says FDA Lifts Clinical Hold On Phase 1/2 Trial Of VX-880 To Treat Type 1 Diabetes

Vertex Pharma Says FDA Lifts Clinical Hold On Phase 1/2 Trial Of VX-880 To Treat Type 1 Diabetes

Vertex Pharmaceuticals Inc. (VRTX) announced Tuesday that the U.S. Food and Drug Administration (FDA) has lifted the clinical hold placed on the Phase 1/2 clinical trial of VX-880, an investigational stem cell-derived, fully differentiated pancreatic islet cell replacement therapy for people with type 1 diabetes (T1D) with impaired hypoglycemic awareness and severe hypoglycemia.
RTTNews | 969 days ago
TSX Ends More Than 1% Up

TSX Ends More Than 1% Up

After a weak start and a subsequent recovery, the Canadian market slipped into negative territory around early afternoon on Friday, but gained in strength after that with stocks from industrials, financials, utilities and consumer staples attracting buyers.
RTTNews | 8h 9min ago
Dollar Rises Against Major Counterparts

Dollar Rises Against Major Counterparts

The U.S. dollar climbed higher on Friday, extending gains from the previous session following U.S. President Donald Trump's announcement that the 25% tariffs on Canada and Mexico, and an additional 10% on China, will take effect early next week.
RTTNews | 8h 43min ago
German Inflation Steady At 2.3% In February

German Inflation Steady At 2.3% In February

Consumer price inflation in Germany was unchanged in February, while the core price growth slowed as the cost of food increased strongly, preliminary data from the statistical office Destatis showed on Friday.
RTTNews | 11h 10min ago
Canadian Market Modestly Higher In Cautious Trade

Canadian Market Modestly Higher In Cautious Trade

The Canadian benchmark S&P/TSX Composite Index is modestly higher in late afternoon trades on Friday with stocks turning in a mixed performance. Worries about U.S. tariffs and their potential impact on global economic growth appear to be weighing on sentiment. Investors are also digesting the nation's GDP report and U.S. PCE reading.
RTTNews | 11h 23min ago