Omeros Says FDA Grants Orphan Drug Designation To MASP-3 Inhibitor OMS906

RTTNews | 894 일 전
Omeros Says FDA Grants Orphan Drug Designation To MASP-3 Inhibitor OMS906

(RTTNews) - Omeros Corp (OMER) announced Friday that OMS906 has received orphan drug designation from the U.S. Food and Drug Administration (FDA) for the treatment of paroxysmal nocturnal hemoglobinuria (PNH).

OMS906 targets mannan-binding lectin-associated serine protease-3 (MASP-3), the key activator of the alternative pathway of the complement system. MASP-3 converts pro-complement factor D (pro-CFD) to mature CFD.

PNH is a rare, life-threatening disease characterized by red blood cell destruction, blood clots and impaired bone marrow function.

Based on its mechanism of action as well as the pharmacokinetic/pharmacodynamic (PK/PD) profile shown in a completed Phase 1 study, OMS906 has the potential to offer a favorable safety profile and more convenient dosing than other drugs on the market or in development for PNH.

Omeros recently completed a Phase 1 trial of OMS906 in healthy subjects and expects to begin enrollment this summer in a clinical trial assessing OMS906 in PNH patients who have had an unsatisfactory response to the C5 inhibitor ravulizumab.

The company is also targeting efficacy data in populations of treatment-naïve PNH and C3 glomerulopathy patients by early 2023. Based on the results of the completed Phase 1 trial, administration of OMS906 is expected to be once monthly to once quarterly intravenously or subcutaneously.

For More Such Health News, visit rttnews.com

read more
European Economic News Preview: Germany Industrial Output, Trade Data Due

European Economic News Preview: Germany Industrial Output, Trade Data Due

Industrial production and foreign trade from Germany and retail sales from the euro area are the top economic news due on Thursday. At 2.00 am ET, Destatis is slated to issue Germany's industrial output and trade figures. Exports are expected to rebound 2.0 percent on month in November and imports to climb 0.7 percent.
RTTNews | 5 시간 29 분 전
China Inflation Eases To 0.1%; PPI Continues To Drop

China Inflation Eases To 0.1%; PPI Continues To Drop

China's consumer price inflation softened further in December and producer prices declined for 27 consecutive months despite Beijing initiating stimulus measures to revive domestic demand. Consumer prices grew only 0.1 percent on a yearly basis in December, slower than the 0.2 percent increase seen in November, figures from the National Bureau of Statistics revealed on Thursday.
RTTNews | 5 시간 36 분 전
Sensex, Nifty Open Lower On Weak Global Cues

Sensex, Nifty Open Lower On Weak Global Cues

Indian shares were subdued on Thursday, tracking weak cues from global markets as Chinese inflation data disappointed and reports suggested that U.S. President-elect Donald Trump was mulling a national economic emergency declaration to provide legal justification for a series of universal tariffs on allies and adversaries.
RTTNews | 7 시간 49 분 전
Asian Markets Mostly Lower

Asian Markets Mostly Lower

Asian stock markets are trading mostly lower on Thursday, following the mixed cues from Wall Street overnight, amid uncertainty about the outlook for interest rates following mixed U.S. jobs data. The minutes of the US Fed's latest monetary policy meeting also did not provide much insight into interest rates other than to suggest officials plan to take a "careful approach" to future decisions.
RTTNews | 9 시간 2 분 전
Australian Market Slightly Trims Early Losses In Mid-market

Australian Market Slightly Trims Early Losses In Mid-market

The Australian market slightly trimmed the early losses and is trading notably lower in mid-market moves on Thursday. The benchmark S&P/ASX 200 is falling to near the 8,300 level, with weakness across most sectors led by technology and financial stocks. Gold miners remain the only bright spot.
RTTNews | 9 시간 41 분 전
Sensex, Nifty Likely To Open On Cautious Note

Sensex, Nifty Likely To Open On Cautious Note

Indian shares are seen opening on a cautious note Thursday as investors await cues from the upcoming Q3 earnings season and prepare for the highly anticipated U.S. jobs report due on Friday that could shed more light on the Federal Reserve's policy outlook.
RTTNews | 9 시간 53 분 전
Thai Shares May Tick Higher On Thursday

Thai Shares May Tick Higher On Thursday

The Thai stock market has alternated between positive and negative finishes through the last four trading days since the end of the two-day slide in which it had slumped more than 20 points or 1.5 percent. The Stock Exchange of Thailand now sits just beneath the 1,390-point plateau and they're expected to open slightly to the upside on Thursday.
RTTNews | 10 시간 24 분 전